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中国科学院广州生物医药与健康研究院外专千人团队2018年5月招聘博士后

2 Postdoctoral Positions to study chromatin function and structure in stem and reprogrammed cells at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

Guangzhou,Chia Pia Cosma Reprogramming and Regeneration Laboratory

 

The Guangzhou Institutes of Biomedicine and Health (GIBH, http://english.gibh.cas.cn/about/at/) is focused  in  research  areas  including  stem  cell  and regenerative  medicine,  chemical  biology,  immunology  and  infectious  diseases.  Aimed  to achieve  the goal of "Healthy  China"  strategy  and satisfy  human  health demands,  GIBH is exploring disease mechanism with the cutting--edge  technologies and developing innovative protocols   for  disease   control   and  prevention.   It  provides   excellent   R&D  platform   in biomedicine and functions as an incubator for bioengineering and pharmaceutical industries to support local economic development as well as national strategic R&D programs. Reprogramming and Regeneration Laboratory

Pia Cosmas group is an internationally recognized  laboratory (http://piacosmalab.com/) having as main  objective  to  investigate  the   mechanisms controlling  the  reprogramming  of somatic  cells,  and  to determine  if this  reprogramming contributes to tissue regeneration in higher vertebrates. Cosmas group has discovered that activation  of  the Wnt--catenin    signalling    pathway  enhances    cell--‐fusion--mediated reprogramming of a variety of somatic cells and studied extensively the mechanism behind (Lluis  et al.,  Cell  Stem  Cell  2008;  Stem  Cells  2010;  PNAS  2011;  Aulicino  et al.,  Stem  Cell Report 2014; Marucci et al. Cell Reports 2014; De Jaime--Soguero  et al. Plos Genetics 2017; Arumugam  et  al.  Nature  Genetics,  under  revision).  Cosmas  group  demonstrated  that regeneration  of the retina, dopaminergic  neurons in Parkinsons  disease and of liver after hepatectomy is possible via Wnt controlled cell--‐fusion--mediated  reprogramming (Sanges et al., Cell Reports 2013; J. of Clinical Investigation  2016; Pesaresi et al. eBioMedicine  2018; Altarche--Xifroet al., eBioMedicine 2016; Pedone et al., Cell Reports 2017).  

In addition, Cosmas Group has a long interest in studying gene and chromatin function (Cantone et al, Cell 2009). Recently using super resolution microscopy (STORM), the group has  identified  a  new  model  of  chromatin  fiber  assembly  and  how  the  fiber  changes  in somatic and embryonic stem cells (Ricci et al. Cell 2015, Neguembor et al., NAR 2017).  

We are currently studying the changes in chromatin structure and organization during somatic cell reprogramming and differentiation, to determine how chromatin fibers can be rearranged to overcome epigenetic barriers to gain pluripotency.  

Post Description and Candidate requirements

    The Cosma group is looking for a highly motivated research scientist with consolidated expertise in biomedicine, biophysics or related disciplines. The candidate will hold a PhD and will have experience with cell culture and imaging methods. Experience in the area of super resolution microscopy and/or CRISPR/Cas engineering methods will be considered an added value.  If necessary,  the successful  candidate  will be trained  in STORM  microscopy  at the CRG, Barcelona, Spain for few months before to move and work at the GIBH, Guangzhou.  Conditions

    The  offer  is  to  cover  a  Postdoctoral  position  with  a  very  competitive  salary  that  will  be

well matched relative to the cost of living in Barcelona and Guangzhou.

Starting Date

The fellowship will start ideally as soon as the candidate is hired.

Application Procedure

All applications  must be addressed  to Pia Cosma;  and include  a full CV with contact details,  a  cover  motivation  letter  and  contacts  of  2--3  references.  Please  submit  your application at: pia.cosma@gmail.com

Deadline June 30 2018 (note that applications will be continually monitored)

 

必备条件:年龄35岁以下,已取得博士学位,且取得学位不得超过3年。

来源:

http://www.gibh.cas.cn/rczp/ypxx/201805/t20180528_5018374.html

 

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